Version 5.4
Homo sapiens Protein: CDX4
Summary
InnateDB Protein IDBP-77109.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDX4
Protein Name caudal type homeobox 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362613
InnateDB Gene IDBG-77107 (CDX4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0009952 anterior/posterior pattern specification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060711 labyrinthine layer development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000047 Helix-turn-helix motif
IPR001356 Homeobox domain
IPR006820 Caudal-like activation domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PF04731
PRINTS PR00031
PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14627
PhosphoSite PhosphoSite-O14627
TrEMBL
UniProt Splice Variant
Entrez Gene 1046
UniGene Hs.553488
RefSeq NP_005184
HUGO HGNC:1808
OMIM 300025
CCDS CCDS14424
HPRD 02065
IMGT
EMBL AF003530 AF029877 AF029878 AF029879 AL450108 BC128233 CH471104
GenPept AAB66319 AAD01894 AAI28234 CAI40795 EAW98667

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca