InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLS

Summary

InnateDB Protein

IDBP-77591.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLS

Protein Name

glutaminase

Synonyms

AAD20; GAC; GAM; GLS1; KGA;

Species

Homo sapiens

Ensembl Protein

ENSP00000340689

InnateDB Gene

IDBG-77587 (GLS)

Protein Structure

UniProt Annotation

Function

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

Subcellular Localization

Isoform 1: Cytoplasm, cytosol.Isoform 3: Mitochondrion.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. {ECO:0000269PubMed:11015561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004359	glutaminase activity
GO:0005515	protein binding

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0006541	glutamine metabolic process
GO:0006543	glutamine catabolic process
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0008652	cellular amino acid biosynthetic process
GO:0014047	glutamate secretion
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0051289	protein homotetramerization