Version 5.4
Homo sapiens Protein: PGK1
Summary
InnateDB Protein IDBP-77812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGK1
Protein Name phosphoglycerate kinase 1
Synonyms HEL-S-68p; MIG10; PGKA;
Species Homo sapiens
Ensembl Protein ENSP00000362413
InnateDB Gene IDBG-77810 (PGK1)
Protein Structure
UniProt Annotation
Function In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
Subcellular Localization Cytoplasm.
Disease Associations Phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:300653]: A condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations. {ECO:0000269PubMed:1547346, ECO:0000269PubMed:1586722, ECO:0000269PubMed:2001457, ECO:0000269PubMed:6933565, ECO:0000269PubMed:6941312, ECO:0000269PubMed:8043870, ECO:0000269PubMed:8615693, ECO:0000269PubMed:8673469, ECO:0000269PubMed:9744480}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 58 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004618 phosphoglycerate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0030855 epithelial cell differentiation
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001576 Phosphoglycerate kinase
PFAM PF00162
PRINTS PR00477
PIRSF PIRSF000724
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P00558
PhosphoSite PhosphoSite-P00558
TrEMBL V9HWF4
UniProt Splice Variant
Entrez Gene 5230
UniGene Hs.78771
RefSeq NP_000282
HUGO HGNC:8896
OMIM 311800
CCDS CCDS14438
HPRD 02412
IMGT
EMBL AB062432 AK291081 AK295182 AK298855 AK301740 AK312280 AL049589 AY423725 BC023234 BC103752 BC104837 BC113568 CH471104 CR456716 EU794645 L00160 M11958 M11959 M11960 M11961 M11962 M11963 M11964 M11965 M11966 M11967 M11968 M34017 V00572
GenPept AAA60078 AAA60079 AAA60103 AAH23234 AAI03753 AAI04838 AAI13569 AAS00488 ACJ13699 BAB93495 BAF83770 BAG35209 BAG58187 BAG60978 BAH13545 CAA23835 CAG32997 CAI42951 EAW98604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca