InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PGK1

Summary

InnateDB Gene

IDBG-77810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGK1

Gene Name

phosphoglycerate kinase 1

Synonyms

HEL-S-68p; MIG10; PGKA

Species

Homo sapiens

Ensembl Gene

ENSG00000102144

Encoded Proteins

IDBP-77812

phosphoglycerate kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq, Oct 2008]
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:78065188-78129296

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000373316	ENSP00000362413
ENST00000477335
ENST00000491291
ENST00000474281
ENST00000476531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	58 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004618	phosphoglycerate kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0016310	phosphorylation
GO:0030855	epithelial cell differentiation
GO:0044281	small molecule metabolic process