InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P4HA1

Summary

InnateDB Protein

IDBP-78063.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HA1

Protein Name

prolyl 4-hydroxylase, alpha polypeptide I

Synonyms

P4HA;

Species

Homo sapiens

Ensembl Protein

ENSP00000263556

InnateDB Gene

IDBG-78057 (P4HA1)

Protein Structure

UniProt Annotation

Function

Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Subcellular Localization

Endoplasmic reticulum lumen.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199	collagen fibril organization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR005123 Oxoglutarate/iron-dependent dioxygenase
IPR006620 Prolyl 4-hydroxylase, alpha subunit
IPR013026 Tetratricopeptide repeat-containing domain
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
IPR019734 Tetratricopeptide repeat

PFAM

PF03171
PF13640
PF08336
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00702
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13674