InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP10

Summary

InnateDB Protein

IDBP-78474.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP10

Protein Name

caspase 10, apoptosis-related cysteine peptidase

Synonyms

ALPS2; FLICE2; MCH4;

Species

Homo sapiens

Ensembl Protein

ENSP00000353250

InnateDB Gene

IDBG-78470 (CASP10)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp--AMC and Asp-Glu-Val-Asp--AMC. {ECO:0000269PubMed:11717445}.Isoform C is proteolytically inactive. {ECO:0000269PubMed:11717445}.

Subcellular Localization

Disease Associations

Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269PubMed:10412980, ECO:0000269PubMed:16446975}. Note=The disease is caused by mutations affecting the gene represented in this entry.Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. {ECO:0000269PubMed:12010812}. Note=The gene represented in this entry is involved in disease pathogenesis.Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269PubMed:11973654}. Note=The gene represented in this entry is involved in disease pathogenesis.

Tissue Specificity

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.

Experimentally validated
Total	69 [view]
Protein-Protein	68 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0035877	death effector domain binding
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0097190	apoptotic signaling pathway