InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CASP10

Summary

InnateDB Gene

IDBG-78470.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP10

Gene Name

caspase 10, apoptosis-related cysteine peptidase

Synonyms

ALPS2; FLICE2; MCH4

Species

Homo sapiens

Ensembl Gene

ENSG00000003400

Encoded Proteins

IDBP-78472

caspase 10, apoptosis-related cysteine peptidase

IDBP-78474

caspase 10, apoptosis-related cysteine peptidase

IDBP-78476

caspase 10, apoptosis-related cysteine peptidase

IDBP-78478

caspase 10, apoptosis-related cysteine peptidase

IDBP-78480

caspase 10, apoptosis-related cysteine peptidase

IDBP-78482

caspase 10, apoptosis-related cysteine peptidase

IDBP-388320

caspase 10, apoptosis-related cysteine peptidase

IDBP-388321

caspase 10, apoptosis-related cysteine peptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17822854

CASP10 is an initiator caspase in the death receptor (DR)-dependent apoptotic pathway with multiple identified splice variants. The prodomain-only isoform of CASP10, Caspase-10g, may play a regulatory role in the NF-kappaB pathways.

Entrez Gene

Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:201182881-201229406

Strand

Forward strand

Band

q33.1

Transcripts

ENST00000272879	ENSP00000272879
ENST00000360132	ENSP00000353250
ENST00000286186	ENSP00000286186
ENST00000346817	ENSP00000237865
ENST00000313728	ENSP00000314599
ENST00000374650	ENSP00000363781
ENST00000438843	ENSP00000401914
ENST00000448480	ENSP00000396835
ENST00000460140
ENST00000484926
ENST00000492363
ENST00000471191
ENST00000485408

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.

Experimentally validated
Total	69 [view]
Protein-Protein	68 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0031625	ubiquitin protein ligase binding
GO:0035877	death effector domain binding
GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0097190	apoptotic signaling pathway