Version 5.4
Homo sapiens Protein: CASP10
Summary
InnateDB Protein IDBP-78482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP10
Protein Name caspase 10, apoptosis-related cysteine peptidase
Synonyms ALPS2; FLICE2; MCH4;
Species Homo sapiens
Ensembl Protein ENSP00000363781
InnateDB Gene IDBG-78470 (CASP10)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 68 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0035877 death effector domain binding
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031265 CD95 death-inducing signaling complex
GO:0097342 ripoptosome
Protein Structure and Domains
PDB ID
InterPro IPR001875 Death effector domain
IPR011029 Death-like domain
PFAM PF01335
PRINTS
PIRSF
SMART SM00031
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92851
PhosphoSite PhosphoSite-Q92851
TrEMBL
UniProt Splice Variant
Entrez Gene 843
UniGene Hs.605938
RefSeq XP_005246968
HUGO HGNC:1500
OMIM 601762
CCDS
HPRD 03458
IMGT
EMBL AB038979 AC007283 AF111344 AF111345 AJ487678 AJ487679 AY690601 BC042844 CH471063 EF050529 U60519 U86214
GenPept AAB46730 AAC50644 AAD28402 AAD28403 AAH42844 AAU00989 AAY24291 ABJ53426 BAB32553 BAB32554 CAD32371 CAD32372 EAW70248 EAW70249

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca