InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF335

Summary

InnateDB Protein

IDBP-78668.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF335

Protein Name

zinc finger protein 335

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325326

InnateDB Gene

IDBG-78666 (ZNF335)

Protein Structure

UniProt Annotation

Function

Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. {ECO:0000269PubMed:12215545, ECO:0000269PubMed:18180299, ECO:0000269PubMed:23178126}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12215545}.

Disease Associations

Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation. {ECO:0000269PubMed:23178126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12215545, ECO:0000269PubMed:23178126}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002052	positive regulation of neuroblast proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0010468	regulation of gene expression
GO:0021895	cerebral cortex neuron differentiation
GO:0040029	regulation of gene expression, epigenetic
GO:0048812	neuron projection morphogenesis
GO:0048854	brain morphogenesis
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050767	regulation of neurogenesis
GO:0050769	positive regulation of neurogenesis
GO:0051569	regulation of histone H3-K4 methylation
GO:0080182	histone H3-K4 trimethylation