Mus musculus Protein: Twist2
Summary
InnateDB Protein IDBP-787903.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Twist2
Protein Name twist basic helix-loop-helix transcription factor 2
Synonyms bHLHa39; Dermo1;
Species Mus musculus
Ensembl Protein ENSMUSP00000139531
InnateDB Gene IDBG-181549 (Twist2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0044092 negative regulation of molecular function
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060325 face morphogenesis
GO:0061303 cornea development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:104685
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D6P6
UniProt Splice Variant
Entrez Gene 13345
UniGene
RefSeq
MGI ID
MGI Symbol Twist2
OMIM
CCDS CCDS15166
HPRD
IMGT
EMBL AC109197 AC164068 BC090636 CH466520
GenPept AAH90636 EDL40020