Version 5.4
Mus musculus Protein: Twist2
Summary
InnateDB Protein IDBP-787903.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Twist2
Protein Name twist basic helix-loop-helix transcription factor 2
Synonyms bHLHa39; Dermo1;
Species Mus musculus
Ensembl Protein ENSMUSP00000139531
InnateDB Gene IDBG-181549 (Twist2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0044092 negative regulation of molecular function
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060325 face morphogenesis
GO:0061303 cornea development in camera-type eye
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:104685
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D6P6
UniProt Splice Variant
Entrez Gene 13345
UniGene
RefSeq
MGI ID
MGI Symbol Twist2
OMIM
CCDS CCDS15166
HPRD
IMGT
EMBL AC109197 AC164068 BC090636 CH466520
GenPept AAH90636 EDL40020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca