InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAAT

Summary

InnateDB Protein

IDBP-78919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAAT

Protein Name

bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

Synonyms

BACAT; BAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000259407

InnateDB Gene

IDBG-78917 (BAAT)

Protein Structure

UniProt Annotation

Function

Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12810727}.

Disease Associations

Familial hypercholanemia (FHCA) [MIM:607748]: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. {ECO:0000269PubMed:12704386}. Note=The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry.

Tissue Specificity

Expressed in liver, gallbladder mucosa and pancreas. {ECO:0000269PubMed:12810727, ECO:0000269PubMed:2037576}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016290	palmitoyl-CoA hydrolase activity
GO:0016410	N-acyltransferase activity
GO:0016790	thiolester hydrolase activity
GO:0047963	glycine N-choloyltransferase activity
GO:0052815	medium-chain acyl-CoA hydrolase activity
GO:0052816	long-chain acyl-CoA hydrolase activity
GO:0052817	very long chain acyl-CoA hydrolase activity

Biological Process

GO:0001889	liver development
GO:0002152	bile acid conjugation
GO:0006544	glycine metabolic process
GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006699	bile acid biosynthetic process
GO:0008206	bile acid metabolic process
GO:0015721	bile acid and bile salt transport
GO:0019530	taurine metabolic process
GO:0031100	organ regeneration
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF04775
PF08840

PRINTS

PIRSF

PIRSF016521

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14032