Version 5.4
Mus musculus Protein: Birc2
Summary
InnateDB Protein IDBP-789532.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Birc2
Protein Name baculoviral IAP repeat-containing 2
Synonyms Api1; Api2; AW146227; Birc3; cIAP1; cIAP2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48;
Species Mus musculus
Ensembl Protein ENSMUSP00000140049
InnateDB Gene IDBG-133125 (Birc2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 105 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0010243 response to organonitrogen compound
GO:0014070 response to organic cyclic compound
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045471 response to ethanol
GO:0051291 protein heterooligomerization
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0070266 necroptotic process
GO:1902443 negative regulation of ripoptosome assembly involved in necroptotic process
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1902524 positive regulation of protein K48-linked ubiquitination
GO:1902527 positive regulation of protein monoubiquitination
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0001741 XY body
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID MGI:1197009
InterPro IPR001315 CARD domain
IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR001841 Zinc finger, RING-type
IPR011029 Death-like domain
PFAM PF00619
PF00653
PF13639
PF14634
PRINTS
PIRSF
SMART SM00114
SM00238
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11797
UniGene
RefSeq XP_006509896
MGI ID
MGI Symbol Birc2
OMIM
CCDS CCDS22811
HPRD
IMGT
EMBL BC145985 L49433 U88909
GenPept AAC42078 AAC53532 AAI45986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca