InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF20

Summary

InnateDB Protein

IDBP-79058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF20

Protein Name

ring finger protein 20

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000373772

InnateDB Gene

IDBG-79054 (RNF20)

Protein Structure

UniProt Annotation

Function

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. {ECO:0000269PubMed:16307923, ECO:0000269PubMed:16337599, ECO:0000269PubMed:19410543}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:16337599}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	74 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042393	histone binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007165	signal transduction
GO:0010390	histone monoubiquitination
GO:0016574	histone ubiquitination
GO:0030336	negative regulation of cell migration
GO:0031062	positive regulation of histone methylation
GO:0033523	histone H2B ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated