InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RNF20

Summary

InnateDB Gene

IDBG-79054.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF20

Gene Name

ring finger protein 20, E3 ubiquitin protein ligase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000155827

Encoded Proteins

IDBP-79056

ring finger protein 20

IDBP-79058

ring finger protein 20

IDBP-478206

ring finger protein 20

IDBP-477541

ring finger protein 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:101533851-101563344

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000374819	ENSP00000363952
ENST00000389120	ENSP00000373772
ENST00000479306	ENSP00000419201
ENST00000481046
ENST00000466817	ENSP00000418924
ENST00000478072

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	74 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042393	histone binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007165	signal transduction
GO:0010390	histone monoubiquitination
GO:0016574	histone ubiquitination
GO:0030336	negative regulation of cell migration
GO:0031062	positive regulation of histone methylation
GO:0033523	histone H2B ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0033503	HULC complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028309

View Gene Order

ENSBTAG00000009516

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.621818 Hs.729085

RefSeq

NM_019592

HUGO

OMIM

CCDS

CCDS35084

HPRD

07410

IMGT

EMBL

GenPept

RNA Seq Atlas