Homo sapiens Gene: RNF20
Summary
InnateDB Gene IDBG-79054.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF20
Gene Name ring finger protein 20, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155827
Encoded Proteins
ring finger protein 20
ring finger protein 20
ring finger protein 20
ring finger protein 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:101533851-101563344
Strand Forward strand
Band q31.1
Transcripts
ENST00000374819 ENSP00000363952
ENST00000389120 ENSP00000373772
ENST00000479306 ENSP00000419201
ENST00000481046
ENST00000466817 ENSP00000418924
ENST00000478072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042393 histone binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0010390 histone monoubiquitination
GO:0016574 histone ubiquitination
GO:0030336 negative regulation of cell migration
GO:0031062 positive regulation of histone methylation
GO:0033523 histone H2B ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0033503 HULC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL C9J0A5 C9JWJ4
UniProt Splice Variant
Entrez Gene 56254
UniGene Hs.621818 Hs.729085
RefSeq NM_019592
HUGO HGNC:10062
OMIM 607699
CCDS CCDS35084
HPRD 07410
IMGT
EMBL AL353621 AL591377
GenPept
RNA Seq Atlas 56254