InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMC2

Summary

InnateDB Protein

IDBP-79197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMC2

Protein Name

structural maintenance of chromosomes 2

Synonyms

CAP-E; CAPE; SMC-2; SMC2L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000286398

InnateDB Gene

IDBG-79195 (SMC2)

Protein Structure

UniProt Annotation

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269PubMed:11136719}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10958694}. Cytoplasm {ECO:0000269PubMed:10958694}. Chromosome {ECO:0000269PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	51 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0007076	mitotic chromosome condensation
GO:0010032	meiotic chromosome condensation
GO:0045132	meiotic chromosome segregation
GO:0051276	chromosome organization
GO:0051383	kinetochore organization

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0000796	condensin complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome