InnateDB Protein
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IDBP-79239.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VDAC2
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Protein Name
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voltage-dependent anion channel 2
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Synonyms
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POR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361686
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InnateDB Gene
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IDBG-79237 (VDAC2)
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Protein Structure
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|
Function |
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000269PubMed:7539795}.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues examined.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
60
[view]
|
Protein-Protein |
57
[view]
|
Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001925
Porin, eukaryotic type
IPR027246
Eukaryotic porin/Tom40
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PFAM |
PF01459
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PRINTS |
PR00185
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P45880
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PhosphoSite |
PhosphoSite-P45880
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TrEMBL |
Q5JSD2
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UniProt Splice Variant |
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Entrez Gene |
7417
|
UniGene |
Hs.605824
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RefSeq |
NP_003366
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HUGO |
HGNC:12672
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OMIM |
193245
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CCDS |
CCDS7348
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HPRD |
01904
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IMGT |
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EMBL |
AF152220
AF152221
AF152222
AF152223
AF152224
AF152225
AF152226
AF152227
AL390034
AL392111
BC000165
BC012883
BC072407
CH471083
CR456964
L06328
L08666
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GenPept |
AAA60144
AAA60145
AAB59457
AAD40241
AAH00165
AAH12883
AAH72407
CAG33245
CAH73106
CAH73107
CAH73108
CAI40910
CAI40911
CAI40914
EAW54573
EAW54574
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