InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPA1L

Summary

InnateDB Protein

IDBP-79251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA1L

Protein Name

heat shock 70kDa protein 1-like

Synonyms

HSP70-1L; HSP70-HOM; HSP70T; hum70t;

Species

Homo sapiens

Ensembl Protein

ENSP00000364805

InnateDB Gene

IDBG-79249 (HSPA1L)

Protein Structure

UniProt Annotation

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria. {ECO:0000250, ECO:0000269PubMed:24270810}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in spermatids. {ECO:0000269PubMed:9685725}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	115 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006986	response to unfolded protein
GO:0007339	binding of sperm to zona pellucida
GO:0042026	protein refolding

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0008180	COP9 signalosome
GO:0044297	cell body
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34931