Version 5.4
Homo sapiens Gene: HSPA1L
Summary
InnateDB Gene IDBG-79249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA1L
Gene Name heat shock 70kDa protein 1-like
Synonyms HSP70-1L; HSP70-HOM; HSP70T; hum70t
Species Homo sapiens
Ensembl Gene ENSG00000204390
Encoded Proteins
IDBP-79251
heat shock 70kDa protein 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31809619-31815065
Strand Reverse strand
Band p21.33
Transcripts
ENST00000375654 ENSP00000364805
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 115 [view]
Protein-Protein 115 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006986 response to unfolded protein
GO:0007339 binding of sperm to zona pellucida
GO:0042026 protein refolding
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0008180 COP9 signalosome
GO:0044297 cell body
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007033
View Gene Order
ENSBTAG00000025442
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_200624
Attenuation phase pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04612
Antigen processing and presentation pathway
hsa04144
Endocytosis pathway
hsa03040
Spliceosome pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05145
Toxoplasmosis pathway
INOH
PID NCI
Cross-References
SwissProt P34931
TrEMBL
UniProt Splice Variant
Entrez Gene 3305
UniGene Hs.690634
RefSeq NM_005527 XM_005249070 XM_005249071 XM_005249073 XM_005274970 XM_005274973 XM_005274974
HUGO HGNC:5234
OMIM 140559
CCDS CCDS34413
HPRD
IMGT
EMBL AF134726 AL662834 AL671762 AL929592 BA000025 BC034483 CR388202 D85730 DQ383515 M59829
GenPept AAA63228 AAD21817 AAH34483 ABC88476 BAA32521 BAB63301 CAI17736 CAI18215 CAI18463 CAQ09503
RNA Seq Atlas 3305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca