InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOX1

Summary

InnateDB Protein

IDBP-79289.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOX1

Protein Name

NADPH oxidase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362057

InnateDB Gene

IDBG-79287 (NOX1)

Protein Structure

UniProt Annotation

Function

NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.

Subcellular Localization

Cell projection, invadopodium membrane {ECO:0000269PubMed:19755710}; Multi-pass membrane protein {ECO:0000269PubMed:19755710}.

Disease Associations

Tissue Specificity

NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH- 1S is detected only in colon and colon carcinoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0030171	voltage-gated proton channel activity
GO:0046872	metal ion binding
GO:0048365	Rac GTPase binding
GO:0050661	NADP binding

Biological Process

GO:0001525	angiogenesis
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006739	NADP metabolic process
GO:0006801	superoxide metabolic process
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0015992	proton transport
GO:0016477	cell migration
GO:0030198	extracellular matrix organization
GO:0034765	regulation of ion transmembrane transport
GO:0042554	superoxide anion generation
GO:0042743	hydrogen peroxide metabolic process
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045726	positive regulation of integrin biosynthetic process
GO:0045730	respiratory burst
GO:0046330	positive regulation of JNK cascade
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051454	intracellular pH elevation
GO:0055114	oxidation-reduction process
GO:0071455	cellular response to hyperoxia
GO:0071468	cellular response to acidity
GO:0072592	oxygen metabolic process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0043020	NADPH oxidase complex
GO:0071438	invadopodium membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5S8