InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRYGB

Summary

InnateDB Protein

IDBP-79707.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRYGB

Protein Name

crystallin, gamma B

Synonyms

CRYG2; CTRCT39;

Species

Homo sapiens

Ensembl Protein

ENSP00000260988

InnateDB Gene

IDBG-79705 (CRYGB)

Protein Structure

UniProt Annotation

Function

Crystallins are the dominant structural components of the vertebrate eye lens.

Subcellular Localization

Disease Associations

Cataract 39, multiple types (CTRCT39) [MIM:615188]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT39 includes lamellar, anterior polar, and complete cataracts. {ECO:0000269PubMed:23288985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005212	structural constituent of eye lens

Biological Process

GO:0001654	eye development
GO:0002088	lens development in camera-type eye
GO:0007601	visual perception
GO:0070307	lens fiber cell development
GO:0070309	lens fiber cell morphogenesis