InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLG5

Summary

InnateDB Protein

IDBP-79876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG5

Protein Name

discs, large homolog 5 (Drosophila)

Synonyms

LP-DLG; P-DLG5; PDLG;

Species

Homo sapiens

Ensembl Protein

ENSP00000361467

InnateDB Gene

IDBG-79872 (DLG5)

Protein Structure

UniProt Annotation

Function

May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton. {ECO:0000269PubMed:11876824}.

Subcellular Localization

Cell junction {ECO:0000269PubMed:12657639}. Cell membrane {ECO:0000269PubMed:12657639}; Peripheral membrane protein {ECO:0000269PubMed:12657639}. Note=Localized at sites of cell-cell contact.

Disease Associations

Tissue Specificity

Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain. {ECO:0000269PubMed:11876824, ECO:0000269PubMed:12657639, ECO:0000269PubMed:9738934}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008092	cytoskeletal protein binding
GO:0030159	receptor signaling complex scaffold activity

Biological Process

GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030859	polarized epithelial cell differentiation
GO:0030901	midbrain development
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0045176	apical protein localization
GO:0045186	zonula adherens assembly
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0071896	protein localization to adherens junction
GO:0072205	metanephric collecting duct development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR006907 Domain of unknown function DUF622
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM