InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLG5

Summary

InnateDB Gene

IDBG-79872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG5

Gene Name

discs, large homolog 5 (Drosophila)

Synonyms

LP-DLG; P-DLG5; PDLG

Species

Homo sapiens

Ensembl Gene

ENSG00000151208

Encoded Proteins

IDBP-79876

discs, large homolog 5 (Drosophila)

IDBP-381017

discs, large homolog 5 (Drosophila)

IDBP-813662

discs, large homolog 5 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:77790791-77926526

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000372391	ENSP00000361467
ENST00000424842	ENSP00000394797
ENST00000463362
ENST00000475613
ENST00000459739
ENST00000489547
ENST00000484525
ENST00000476354
ENST00000468332	ENSP00000473298
ENST00000466198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008092	cytoskeletal protein binding
GO:0030159	receptor signaling complex scaffold activity

Biological Process

GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030859	polarized epithelial cell differentiation
GO:0030901	midbrain development
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0045176	apical protein localization
GO:0045186	zonula adherens assembly
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0071896	protein localization to adherens junction
GO:0072205	metanephric collecting duct development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021782

View Gene Order

ENSBTAG00000013187

Not yet available

Cross-References

SwissProt

Q8TDM6

TrEMBL

R4GMQ2

UniProt Splice Variant

Entrez Gene

9231

UniGene

Hs.652690 Hs.719507

RefSeq

NM_004747 XM_006718055 XM_006718056 XM_006725121 XM_006725122

HUGO

HGNC:2904

OMIM

604090

CCDS

CCDS7353

HPRD

IMGT

EMBL

AB011155 AB091676 AF352033 AF352034 AL391421 AL450306 BC073996 BC117695 BC146794 U61843

GenPept

AAC61295 AAH73996 AAI17696 AAI46795 AAL83937 AAL83938 BAA25509 BAC65420 CAI12103 CAI12104 CAI17323 CAI17324

RNA Seq Atlas

9231