Homo sapiens Gene: DLG5
Summary
InnateDB Gene IDBG-79872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLG5
Gene Name discs, large homolog 5 (Drosophila)
Synonyms LP-DLG; P-DLG5; PDLG;
Species Homo sapiens
Ensembl Gene ENSG00000151208
Encoded Proteins
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77790791-77926526
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372391 ENSP00000361467
ENST00000424842 ENSP00000394797
ENST00000463362
ENST00000475613
ENST00000459739
ENST00000489547
ENST00000484525
ENST00000476354
ENST00000468332 ENSP00000473298
ENST00000466198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008092 cytoskeletal protein binding
GO:0030159 receptor signaling complex scaffold activity
Biological Process
GO:0006461 protein complex assembly
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0016337 single organismal cell-cell adhesion
GO:0030859 polarized epithelial cell differentiation
GO:0030901 midbrain development
GO:0035556 intracellular signal transduction
GO:0042981 regulation of apoptotic process
GO:0045176 apical protein localization
GO:0045186 zonula adherens assembly
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0071896 protein localization to adherens junction
GO:0072205 metanephric collecting duct development
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.652690 Hs.719507
RefSeq NM_004747 XM_006718055 XM_006718056 XM_006725121 XM_006725122
HUGO
OMIM
CCDS CCDS7353
HPRD 04972
IMGT
EMBL
GenPept
RNA Seq Atlas