InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULF2

Summary

InnateDB Protein

IDBP-79896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULF2

Protein Name

sulfatase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353007

InnateDB Gene

IDBG-79894 (SULF2)

Protein Structure

UniProt Annotation

Function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004065	arylsulfatase activity
GO:0005509	calcium ion binding
GO:0008449	N-acetylglucosamine-6-sulfatase activity
GO:0008484	sulfuric ester hydrolase activity

Biological Process

GO:0001822	kidney development
GO:0002063	chondrocyte development
GO:0003094	glomerular filtration
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0014846	esophagus smooth muscle contraction
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030201	heparan sulfate proteoglycan metabolic process
GO:0032836	glomerular basement membrane development
GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048706	embryonic skeletal system development
GO:0051216	cartilage development
GO:0060348	bone development
GO:0060384	innervation

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0005886	plasma membrane
GO:0009986	cell surface