InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNXB

Summary

InnateDB Protein

IDBP-79911.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNXB

Protein Name

tenascin XB

Synonyms

EDS3; HXBL; TENX; TN-X; TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS;

Species

Homo sapiens

Ensembl Protein

ENSP00000364396

InnateDB Gene

IDBG-79909 (TNXB)

Protein Structure

UniProt Annotation

Function

Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. {ECO:0000269PubMed:17033827}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tenascin-X deficiency (TNXD) [MIM:606408]: TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X- deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle. Isoform XB- short is only expressed in the adrenal gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0007155	cell adhesion
GO:0030036	actin cytoskeleton organization
GO:0032963	collagen metabolic process
GO:0048251	elastic fiber assembly

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005583	fibrillar collagen trimer
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome