Homo sapiens Gene: TNXB
Summary
InnateDB Gene IDBG-79909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNXB
Gene Name tenascin XB
Synonyms EDS3; HXBL; TENX; TN-X; TNX; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS;
Species Homo sapiens
Ensembl Gene ENSG00000168477
Encoded Proteins
tenascin XB
tenascin XB
tenascin XB
tenascin XB
tenascin XB
tenascin XB
tenascin XB
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5\' and 3\' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32041154-32115334
Strand Reverse strand
Band p21.32
Transcripts
ENST00000375247 ENSP00000364396
ENST00000375244 ENSP00000364393
ENST00000451343 ENSP00000407685
ENST00000442721 ENSP00000389946
ENST00000490077
ENST00000498094
ENST00000479795 ENSP00000418248
ENST00000486148
ENST00000611016 ENSP00000483409
ENST00000613214 ENSP00000480067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006641 triglyceride metabolic process
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0030036 actin cytoskeleton organization
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0032963 collagen metabolic process
GO:0043206 extracellular fibril organization
GO:0043506 regulation of JUN kinase activity
GO:0048251 elastic fiber assembly
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005583 fibrillar collagen trimer
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
ECM proteoglycans pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7148
UniGene
RefSeq NM_019105 NM_032470
HUGO HGNC:11976
OMIM 600985
CCDS CCDS4736
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 7148