Version 5.4
Homo sapiens Protein: CTNNAL1
Summary
InnateDB Protein IDBP-80044.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNAL1
Protein Name catenin (cadherin-associated protein), alpha-like 1
Synonyms ACRP; alpha-CATU; CLLP;
Species Homo sapiens
Ensembl Protein ENSP00000363723
InnateDB Gene IDBG-80038 (CTNNAL1)
Protein Structure
UniProt Annotation
Function May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:12270917}. Cell membrane {ECO:0000269PubMed:12270917}; Peripheral membrane protein {ECO:0000269PubMed:12270917}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland. {ECO:0000269PubMed:10542337, ECO:0000269PubMed:12270917, ECO:0000269PubMed:9806841}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 11 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
GO:0007266 Rho protein signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001033 Alpha-catenin
IPR006077 Vinculin/alpha-catenin
PFAM PF01044
PRINTS PR00805
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBT7
PhosphoSite PhosphoSite-Q9UBT7
TrEMBL
UniProt Splice Variant
Entrez Gene 8727
UniGene
RefSeq NP_001273903
HUGO HGNC:2512
OMIM 604785
CCDS CCDS69638
HPRD 09210
IMGT
EMBL AB451283 AB451415 AF006070 AF030233 AF080071 AF134871 AF134872 AF134873 AF134874 AF134875 AF134876 AF134877 AF134878 AF134879 AF134880 AF134881 AF134882 AF134883 AF134884 AF134885 AF134886 AF134887 AF134888 AF135021 AK223230 AL050016 AL354797 AY523969 BC117208 BC117234 CH471105 U97067
GenPept AAC26011 AAC27693 AAC69576 AAC83460 AAF07819 AAF07820 AAF07821 AAI17209 AAI17235 AAR92479 BAD96950 BAG70097 BAG70229 CAB43238 CAI39471 CAI39472 EAW59036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca