InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIMP2

Summary

InnateDB Protein

IDBP-8012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIMP2

Protein Name

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

Synonyms

JTV-1; JTV1; P38;

Species

Homo sapiens

Ensembl Protein

ENSP00000223029

InnateDB Gene

IDBG-8010 (AIMP2)

Protein Structure

UniProt Annotation

Function

Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. {ECO:0000269PubMed:16135753}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.

Experimentally validated
Total	101 [view]
Protein-Protein	98 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0031398	positive regulation of protein ubiquitination
GO:0060510	Type II pneumocyte differentiation