InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHB

Summary

InnateDB Protein

IDBP-806424.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHB

Protein Name

prohibitin

Synonyms

HEL-215; HEL-S-54e; PHB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000479488

InnateDB Gene

IDBG-57598 (PHB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	101 [view]
Protein-Protein	100 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006260	DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0016575	histone deacetylation
GO:0030308	negative regulation of cell growth
GO:0042981	regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050847	progesterone receptor signaling pathway
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071354	cellular response to interleukin-6
GO:0071897	DNA biosynthetic process
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome