Version 5.4
Homo sapiens Gene: PHB
Summary
InnateDB Gene IDBG-57598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHB
Gene Name prohibitin
Synonyms HEL-215; HEL-S-54e; PHB1
Species Homo sapiens
Ensembl Gene ENSG00000167085
Encoded Proteins
IDBP-57600
prohibitin
IDBP-380742
prohibitin
IDBP-380744
prohibitin
IDBP-380746
prohibitin
IDBP-477616
prohibitin
IDBP-483065
prohibitin
IDBP-474373
prohibitin
IDBP-806424
prohibitin
IDBP-806428
prohibitin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq, Jul 2008]
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3\' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49404049-49414905
Strand Reverse strand
Band q21.33
Transcripts
ENST00000300408 ENSP00000300408
ENST00000393345
ENST00000434917 ENSP00000410680
ENST00000419140 ENSP00000393320
ENST00000446735 ENSP00000407828
ENST00000511933
ENST00000504124 ENSP00000426433
ENST00000508009
ENST00000512041 ENSP00000422182
ENST00000506273
ENST00000507748
ENST00000513412
ENST00000511832 ENSP00000425035
ENST00000614445 ENSP00000479488
ENST00000617874 ENSP00000484113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 101 [view]
Protein-Protein 100 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016575 histone deacetylation
GO:0030308 negative regulation of cell growth
GO:0042981 regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050847 progesterone receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0071354 cellular response to interleukin-6
GO:0071897 DNA biosynthetic process
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038845
View Gene Order
ENSBTAG00000017120
Not yet available
Cross-References
SwissProt P35232
TrEMBL A8K401 C9JW96 C9JZ20 D6RBK0 E7ESE2 E9PCW0
UniProt Splice Variant
Entrez Gene 5245
UniGene
RefSeq NM_002634 NM_001281496 NM_001281497 NM_001281715
HUGO HGNC:8912
OMIM 176705
CCDS CCDS11548 CCDS62244
HPRD 01454
IMGT
EMBL AC091180 AK290766 AK302258 AK312649 BC013401 BC095460 BT007411 CH471109 L14272 S85655
GenPept AAB21614 AAH13401 AAH95460 AAO18340 AAP36079 BAF83455 BAG35532 BAG63609 EAW94680 EAW94681
RNA Seq Atlas 5245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca