InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKQ

Summary

InnateDB Protein

IDBP-806501.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKQ

Protein Name

diacylglycerol kinase, theta 110kDa

Synonyms

DAGK; DAGK4; DAGK7;

Species

Homo sapiens

Ensembl Protein

ENSP00000482164

InnateDB Gene

IDBG-6228 (DGKQ)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0033613	activating transcription factor binding
GO:0043274	phospholipase binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0035556	intracellular signal transduction
GO:0070493	thrombin receptor signaling pathway
GO:0070528	protein kinase C signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00609
PF00781
PF00130

PRINTS

PIRSF

SMART

SM00314
SM00045
SM00046
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

1609

UniGene

RefSeq

HUGO

HGNC:2856

OMIM

601207

CCDS

HPRD

IMGT

EMBL

AC019103 BC063801 L38707

GenPept

AAA98749 AAH63801