InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LCK

Summary

InnateDB Protein

IDBP-807796.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCK

Protein Name

LCK proto-oncogene, Src family tyrosine kinase

Synonyms

IMD22; LSK; p56lck; pp58lck; YT16;

Species

Homo sapiens

Ensembl Protein

ENSP00000477713

InnateDB Gene

IDBG-95667 (LCK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	168 [view]
Protein-Protein	168 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0042169	SH2 domain binding
GO:0042609	CD4 receptor binding
GO:0042610	CD8 receptor binding
GO:0042802	identical protein binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0051117	ATPase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006882	cellular zinc ion homeostasis
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0016032	viral process
GO:0016311	dephosphorylation
GO:0030097	hemopoiesis
GO:0030168	platelet activation
GO:0030217	T cell differentiation
GO:0031295	T cell costimulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042493	response to drug
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050690	regulation of defense response to virus by virus
GO:0050852	T cell receptor signaling pathway
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0050900	leukocyte migration
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051249	regulation of lymphocyte activation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000242	pericentriolar material
GO:0001772	immunological synapse
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM