Version 5.4
Homo sapiens Protein: SAP18
Summary
InnateDB Protein IDBP-808154.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAP18
Protein Name Sin3A-associated protein, 18kDa
Synonyms 2HOR0202; SAP18P;
Species Homo sapiens
Ensembl Protein ENSP00000475925
InnateDB Gene IDBG-14135 (SAP18)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
Experimentally validated
Total 111 [view]
Protein-Protein 101 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043065 positive regulation of apoptotic process
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0061574 ASAP complex
Protein Structure and Domains
PDB ID
InterPro IPR010516 Sin3 associated polypeptide p18
IPR017250 Histone deacetylase complex, SAP18 subunit
PFAM PF06487
PRINTS
PIRSF PIRSF037637
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00422
PhosphoSite PhosphoSite-O00422
TrEMBL U3KPY7
UniProt Splice Variant
Entrez Gene 10284
UniGene
RefSeq
HUGO HGNC:10530
OMIM 602949
CCDS
HPRD
IMGT
EMBL AF153608 AK311748 AL158032 AY550970 BC030836 CH471075 CR457035 U78303 U96915
GenPept AAC51322 AAD41090 AAF21220 AAH30836 AAT52216 BAG34691 CAG33316 CAH69949 EAX08291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca