InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAP18

Summary

InnateDB Protein

IDBP-808160.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAP18

Protein Name

Sin3A-associated protein, 18kDa

Synonyms

2HOR0202; SAP18P;

Species

Homo sapiens

Ensembl Protein

ENSP00000481842

InnateDB Gene

IDBG-14135 (SAP18)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.

Experimentally validated
Total	111 [view]
Protein-Protein	101 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043065	positive regulation of apoptotic process
GO:0048025	negative regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0061574	ASAP complex

Protein Structure and Domains

PDB ID

InterPro

IPR010516 Sin3 associated polypeptide p18

PFAM

PF06487

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF153608 AK311748 AL158032 AY550970 BC030836 CH471075 CR457035 U78303 U96915

GenPept

AAC51322 AAD41090 AAF21220 AAH30836 AAT52216 BAG34691 CAG33316 CAH69949 EAX08291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca