InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FDFT1

Summary

InnateDB Protein

IDBP-808465.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FDFT1

Protein Name

farnesyl-diphosphate farnesyltransferase 1

Synonyms

DGPT; ERG9; SQS; SS;

Species

Homo sapiens

Ensembl Protein

ENSP00000481481

InnateDB Gene

IDBG-7593 (FDFT1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004310	farnesyl-diphosphate farnesyltransferase activity
GO:0016491	oxidoreductase activity
GO:0016740	transferase activity
GO:0051996	squalene synthase activity

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0008610	lipid biosynthetic process
GO:0009058	biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002060 Squalene/phytoene synthase
IPR006449 Farnesyl-diphosphate farnesyltransferase
IPR008949 Terpenoid synthase

PFAM

PF00494

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AC069185 AK057726 AK293545 AK300059 AK315993 AK316351 AK316531 AK316534 BC003573 BC009251 BC029641 BT006704 CH471157 CR457033 L06070 L06105 S76822 X69141

GenPept

AAA36645 AAA60582 AAB33404 AAH03573 AAH09251 AAH29641 AAP35350 BAG51957 BAG61868 BAH11529 BAH14364 BAH14722 BAH14902 BAH14905 CAA48896 CAG33314 EAW65628 EAW65629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca