Version 5.4
Homo sapiens Gene: FDFT1
Summary
InnateDB Gene IDBG-7593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FDFT1
Gene Name farnesyl-diphosphate farnesyltransferase 1
Synonyms DGPT; ERG9; SQS; SS
Species Homo sapiens
Ensembl Gene ENSG00000079459
Encoded Proteins
IDBP-7597
farnesyl-diphosphate farnesyltransferase 1
IDBP-361043
farnesyl-diphosphate farnesyltransferase 1
IDBP-584876
farnesyl-diphosphate farnesyltransferase 1
IDBP-583395
farnesyl-diphosphate farnesyltransferase 1
IDBP-590358
farnesyl-diphosphate farnesyltransferase 1
IDBP-598522
farnesyl-diphosphate farnesyltransferase 1
IDBP-601047
farnesyl-diphosphate farnesyltransferase 1
IDBP-598542
farnesyl-diphosphate farnesyltransferase 1
IDBP-598127
farnesyl-diphosphate farnesyltransferase 1
IDBP-584269
farnesyl-diphosphate farnesyltransferase 1
IDBP-589135
farnesyl-diphosphate farnesyltransferase 1
IDBP-599120
farnesyl-diphosphate farnesyltransferase 1
IDBP-596717
farnesyl-diphosphate farnesyltransferase 1
IDBP-808463
farnesyl-diphosphate farnesyltransferase 1
IDBP-808464
farnesyl-diphosphate farnesyltransferase 1
IDBP-808465
farnesyl-diphosphate farnesyltransferase 1
IDBP-808466
farnesyl-diphosphate farnesyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11795573-11839309
Strand Forward strand
Band p23.1
Transcripts
ENST00000220584 ENSP00000220584
ENST00000443614 ENSP00000390367
ENST00000446331
ENST00000530337 ENSP00000431852
ENST00000525283 ENSP00000433985
ENST00000525607 ENSP00000432551
ENST00000529464 ENSP00000434770
ENST00000525900 ENSP00000434714
ENST00000525571
ENST00000527045
ENST00000528812 ENSP00000431749
ENST00000525551
ENST00000530664 ENSP00000432331
ENST00000525954
ENST00000531733
ENST00000531249
ENST00000532266 ENSP00000435900
ENST00000528643 ENSP00000431649
ENST00000525777 ENSP00000436069
ENST00000528729
ENST00000529521
ENST00000538689 ENSP00000444248
ENST00000623368 ENSP00000485229
ENST00000618539 ENSP00000480828
ENST00000615631 ENSP00000481481
ENST00000622850 ENSP00000484122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004310 farnesyl-diphosphate farnesyltransferase activity
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity
GO:0051996 squalene synthase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045338 farnesyl diphosphate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021273
View Gene Order
ENSBTAG00000012432
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL B3KQ95 B4DT56 B7Z1J3
UniProt Splice Variant
Entrez Gene 2222
UniGene
RefSeq NM_001287745 NM_001287742 NM_001287743 NM_001287744 NM_001287747 NM_001287748 NM_001287749 NM_001287750 NM_001287751 NM_004462
HUGO HGNC:3629
OMIM 184420
CCDS CCDS75696 CCDS5985 CCDS75697
HPRD
IMGT
EMBL AC069185 AK057726 AK293545 AK300059 AK315993 AK316351 AK316531 AK316534
GenPept BAG51957 BAG61868 BAH11529 BAH14364 BAH14722 BAH14902 BAH14905
RNA Seq Atlas 2222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca