InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOS2

Summary

InnateDB Protein

IDBP-808942.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS2

Protein Name

nitric oxide synthase 2, inducible

Synonyms

HEP-NOS; INOS; NOS; NOS2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000482291

InnateDB Gene

IDBG-36000 (NOS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	182 [view]
Protein-Protein	163 [view]
Protein-DNA	18 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006809	nitric oxide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR004030 Nitric oxide synthase, N-terminal
IPR008254 Flavodoxin/nitric oxide synthase
IPR012144 Nitric-oxide synthase, eukaryote
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00667
PF02898
PF00258

PRINTS

PR00369
PR00371

PIRSF

PIRSF000333

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9UM94

UniProt Splice Variant

Entrez Gene

4843

UniGene

RefSeq

HUGO

HGNC:7873

OMIM

163730

CCDS

HPRD

IMGT

EMBL

S76479

GenPept

AAD14226