InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERN1

Summary

InnateDB Protein

IDBP-809271.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERN1

Protein Name

endoplasmic reticulum to nucleus signaling 1

Synonyms

hIRE1p; IRE1; IRE1a; IRE1P;

Species

Homo sapiens

Ensembl Protein

ENSP00000475519

InnateDB Gene

IDBG-64539 (ERN1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004521	endoribonuclease activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0070055	HAC1-type intron splice site recognition and cleavage
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response