Version 5.4
Homo sapiens Gene: ERN1
Summary
InnateDB Gene IDBG-64539.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERN1
Gene Name endoplasmic reticulum to nucleus signaling 1
Synonyms hIRE1p; IRE1; IRE1a; IRE1P
Species Homo sapiens
Ensembl Gene ENSG00000178607
Encoded Proteins
IDBP-383434
endoplasmic reticulum to nucleus signaling 1
IDBP-809271
endoplasmic reticulum to nucleus signaling 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20533428
ERN1 (IRE1)/XBP1-mediated signalling plays roles in the coordination of metabolic and immune responses by acting as a regulatory hub, linking endoplasmic reticulum homeostasis with innate immunity and metabolism.
PMID 22883233
Hyperactivated ERN1 (IRE1α) increases TXNIP mRNA stability by reducing levels of a TXNIP destabilizing microRNA, miR-17. In turn, elevated TXNIP protein activates the NLRP3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion.
PMID 23684307
ERN1 binds to cholera toxin in the endoplasmic reticulum to activate RIG-I innate immune signalling.
InnateDB Annotation from Orthologs
Summary
PMID 22883233
[Mus musculus] Hyperactivated Ern1 (IRE1α) increases Txnip mRNA stability by reducing levels of a Txnip destabilizing microRNA, miR-17. In turn, elevated Txnip protein activates the Nlrp3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion. (Demonstrated in human)
PMID 26173697
[Mus musculus] ERN1-mediated persistent reactive oxygen species generation is a mechanism used by macrophages to kill bacterial pathogens that evade the initial oxidative burst.
Entrez Gene
Summary The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64039142-64130819
Strand Reverse strand
Band q23.3
Transcripts
ENST00000433197 ENSP00000401445
ENST00000584041
ENST00000583896
ENST00000583077
ENST00000583028
ENST00000577567
ENST00000579249
ENST00000606895 ENSP00000475519
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004519 endonuclease activity
GO:0004521 endoribonuclease activity
GO:0004540 ribonuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0042802 identical protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007050 cell cycle arrest
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
GO:0070055 HAC1-type intron splice site recognition and cleavage
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
Cellular Component
GO:0005637 nuclear inner membrane
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020715
View Gene Order
ENSBTAG00000016799
Not yet available
Pathways
NETPATH
REACTOME
REACT_18368
IRE1alpha activates chaperones pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.700027
RefSeq NM_001433 XM_006721769
HUGO
OMIM
CCDS CCDS45762
HPRD 04943
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca