InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN1

Summary

InnateDB Protein

IDBP-80959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN1

Protein Name

protein tyrosine phosphatase, non-receptor type 1

Synonyms

PTP1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000360683

InnateDB Gene

IDBG-80957 (PTPN1)

Protein Structure

UniProt Annotation

Function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269PubMed:18819921, ECO:0000269PubMed:21135139, ECO:0000269PubMed:22169477}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:1739967, ECO:0000269PubMed:21135139}; Peripheral membrane protein {ECO:0000269PubMed:1739967, ECO:0000269PubMed:21135139}; Cytoplasmic side {ECO:0000269PubMed:1739967, ECO:0000269PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 170 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	170 [view]
Protein-Protein	167 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016791	phosphatase activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030971	receptor tyrosine kinase binding
GO:0044822	poly(A) RNA binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0009966	regulation of signal transduction
GO:0016311	dephosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030100	regulation of endocytosis
GO:0030168	platelet activation
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031532	actin cytoskeleton reorganization
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
GO:0046626	regulation of insulin receptor signaling pathway
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Cellular Component

GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0097443	sorting endosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF000926

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References