Homo sapiens Gene: PTPN1
Summary
InnateDB Gene IDBG-80957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN1
Gene Name protein tyrosine phosphatase, non-receptor type 1
Synonyms PTP1B;
Species Homo sapiens
Ensembl Gene ENSG00000196396
Encoded Proteins
protein tyrosine phosphatase, non-receptor type 1
protein tyrosine phosphatase, non-receptor type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:50510321-50585241
Strand Forward strand
Band q13.13
Transcripts
ENST00000371621 ENSP00000360683
ENST00000541713 ENSP00000437732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 170 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 170 [view]
Protein-Protein 167 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016791 phosphatase activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030971 receptor tyrosine kinase binding
GO:0044822 poly(A) RNA binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0016311 dephosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030100 regulation of endocytosis
GO:0030168 platelet activation
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031532 actin cytoskeleton reorganization
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Cellular Component
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0097443 sorting endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
Prolactin pathway
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Platelet activation, signaling and aggregation pathway
Regulation of IFNA signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
Integrin alphaIIb beta3 signaling pathway
Immune System pathway
Growth hormone receptor signaling pathway
Platelet Aggregation (Plug Formation) pathway
Interferon gamma signaling pathway
Regulation of IFNG signaling pathway
Hemostasis pathway
KEGG
Adherens junction pathway
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IGF1 pathway
Signaling events mediated by TCPTP
PDGFR-beta signaling pathway
Insulin Pathway
N-cadherin signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt P18031
TrEMBL A8K3M3 B4DSN5
UniProt Splice Variant
Entrez Gene 5770
UniGene Hs.417549 Hs.622449
RefSeq NM_001278618 NM_002827
HUGO HGNC:9642
OMIM 176885
CCDS CCDS13430 CCDS63309
HPRD
IMGT
EMBL AK290638 AK299830 AK316563 AL034429 AL133230 BC015660 BC018164 BT006752 CH471077 M31724 M33684 M33685 M33686 M33687 M33688 M33689
GenPept AAA60157 AAA60158 AAA60223 AAH15660 AAH18164 AAP35398 BAF83327 BAG38152 BAG61697 CAC00618 CAI23215 EAW75626
RNA Seq Atlas 5770