InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC11A1

Summary

InnateDB Protein

IDBP-80971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC11A1

Protein Name

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Synonyms

LSH; NRAMP; NRAMP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000233202

InnateDB Gene

IDBG-80969 (SLC11A1)

Protein Structure

UniProt Annotation

Function

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	0
Protein-DNA	6 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0046915	transition metal ion transmembrane transporter activity
GO:0051139	metal ion:proton antiporter activity

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001818	negative regulation of cytokine production
GO:0001819	positive regulation of cytokine production
GO:0002309	T cell proliferation involved in immune response
GO:0002369	T cell cytokine production
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006810	transport
GO:0006826	iron ion transport
GO:0006828	manganese ion transport
GO:0006876	cellular cadmium ion homeostasis
GO:0006879	cellular iron ion homeostasis
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007035	vacuolar acidification
GO:0009617	response to bacterium
GO:0010628	positive regulation of gene expression
GO:0015707	nitrite transport
GO:0032147	activation of protein kinase activity
GO:0032496	response to lipopolysaccharide
GO:0032623	interleukin-2 production
GO:0032632	interleukin-3 production
GO:0032729	positive regulation of interferon-gamma production
GO:0034341	response to interferon-gamma
GO:0042060	wound healing
GO:0042116	macrophage activation
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0043091	L-arginine import
GO:0045342	MHC class II biosynthetic process
GO:0045730	respiratory burst
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048002	antigen processing and presentation of peptide antigen
GO:0048255	mRNA stabilization
GO:0050766	positive regulation of phagocytosis
GO:0050829	defense response to Gram-negative bacterium
GO:0051701	interaction with host
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport
GO:0060586	multicellular organismal iron ion homeostasis
GO:0070574	cadmium ion transmembrane transport
GO:0070839	divalent metal ion export
GO:0071421	manganese ion transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005764	lysosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009279	cell outer membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031902	late endosome membrane
GO:0070821	tertiary granule membrane