Version 5.4
Homo sapiens Protein: ARHGEF2
Summary
InnateDB Protein IDBP-809786.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF2
Protein Name Rho/Rac guanine nucleotide exchange factor (GEF) 2
Synonyms GEF; GEF-H1; GEFH1; LFP40; P40;
Species Homo sapiens
Ensembl Protein ENSP00000476916
InnateDB Gene IDBG-103338 (ARHGEF2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
PFAM PF00621
PF00169
PF00130
PRINTS
PIRSF
SMART SM00325
SM00233
SM00109
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL V9GZ14
UniProt Splice Variant
Entrez Gene 9181
UniGene
RefSeq XP_005245646
HUGO HGNC:682
OMIM 607560
CCDS
HPRD
IMGT
EMBL AL355388 CH471121
GenPept EAW53012 EAW53017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca