Version 5.4
Homo sapiens Protein: PCGF2
Summary
InnateDB Protein IDBP-810210.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCGF2
Protein Name polycomb group ring finger 2
Synonyms MEL-18; RNF110; ZNF144;
Species Homo sapiens
Ensembl Protein ENSP00000482063
InnateDB Gene IDBG-775251 (PCGF2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
Experimentally validated
Total 68 [view]
Protein-Protein 66 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0016573 histone acetylation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0070301 cellular response to hydrogen peroxide
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35227
PhosphoSite PhosphoSite-P35227
TrEMBL A0A024R1V6
UniProt Splice Variant
Entrez Gene 7703
UniGene
RefSeq XP_005257697
HUGO HGNC:12929
OMIM 600346
CCDS CCDS32638
HPRD
IMGT
EMBL AC006449 BC004858 BC024255 BX647429 CH471152 D13969
GenPept AAH04858 AAH24255 BAA03074 EAW60528 EAW60529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca