Version 5.4
Homo sapiens Gene: PCGF2
Summary
InnateDB Gene IDBG-775251.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCGF2
Gene Name polycomb group ring finger 2
Synonyms MEL-18; RNF110; ZNF144
Species Homo sapiens
Ensembl Gene ENSG00000277258
Encoded Proteins
IDBP-810210
polycomb group ring finger 2
IDBP-810213
polycomb group ring finger 2
IDBP-810215
polycomb group ring finger 2
IDBP-810224
polycomb group ring finger 2
IDBP-810227
polycomb group ring finger 2
IDBP-810229
polycomb group ring finger 2
IDBP-810233
polycomb group ring finger 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:38733897-38749817
Strand Reverse strand
Band q12
Transcripts
ENST00000616199 ENSP00000482063
ENST00000610747 ENSP00000483741
ENST00000611883 ENSP00000478970
ENST00000616129 ENSP00000484201
ENST00000618941 ENSP00000481656
ENST00000618506 ENSP00000484721
ENST00000620225 ENSP00000482815
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
Experimentally validated
Total 68 [view]
Protein-Protein 66 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0009952 anterior/posterior pattern specification
GO:0016573 histone acetylation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0070301 cellular response to hydrogen peroxide
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0001739 sex chromatin
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_007144 XM_005257640 XM_005257641 XM_005257642 XM_006725342 XM_006725344 XM_006725345
HUGO
OMIM
CCDS CCDS32638
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca