Version 5.4
Homo sapiens Protein: EIF4G3
Summary
InnateDB Protein IDBP-810504.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4G3
Protein Name eukaryotic translation initiation factor 4 gamma, 3
Synonyms eIF-4G 3; eIF4G 3; eIF4GII;
Species Homo sapiens
Ensembl Protein ENSP00000473510
InnateDB Gene IDBG-93019 (EIF4G3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000339 RNA cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0016281 eukaryotic translation initiation factor 4F complex
Protein Structure and Domains
PDB ID
InterPro IPR003307 W2 domain
IPR003890 MIF4G-like, type 3
IPR003891 Initiation factor eIF-4 gamma, MA3
IPR016024 Armadillo-type fold
PFAM PF02020
PF02854
PF02847
PRINTS
PIRSF
SMART SM00515
SM00543
SM00544
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43432
PhosphoSite PhosphoSite-O43432
TrEMBL Q59GJ0
UniProt Splice Variant
Entrez Gene 8672
UniGene
RefSeq NP_001185731
HUGO HGNC:3298
OMIM 603929
CCDS CCDS55580
HPRD
IMGT
EMBL AB209119 AF012072 AL031005 AL358392 AL606477 AL627311 AL672037 BC030578 BC094683 BC136643 CH471134 Z34918
GenPept AAC02903 AAH30578 AAH94683 AAI36644 BAD92356 CAA84397 CAI12155 CAI12534 CAI14553 EAW94956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca