Version 5.4
Homo sapiens Protein: HSH2D
Summary
InnateDB Protein IDBP-811015.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSH2D
Protein Name hematopoietic SH2 domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000482604
InnateDB Gene IDBG-35350 (HSH2D)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0002903 negative regulation of B cell apoptotic process
GO:0009967 positive regulation of signal transduction
GO:0042110 T cell activation
GO:0051902 negative regulation of mitochondrial depolarization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JZ2
PhosphoSite PhosphoSite-Q96JZ2
TrEMBL K7ES08
UniProt Splice Variant
Entrez Gene 84941
UniGene
RefSeq NP_116244
HUGO HGNC:24920
OMIM 608349
CCDS CCDS74304
HPRD
IMGT
EMBL AC008894 AC020911 AK027792 AK131222 AY319652 BC025237 CH471106
GenPept AAH25237 AAQ81285 BAB55372 BAD18408 EAW84529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca