Version 5.4
Homo sapiens Gene: HSH2D
Summary
InnateDB Gene IDBG-35350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSH2D
Gene Name hematopoietic SH2 domain containing
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196684
Encoded Proteins
IDBP-763621
IDBP-760338
IDBP-760065
IDBP-811015
hematopoietic SH2 domain containing
IDBP-811022
hematopoietic SH2 domain containing
IDBP-811024
hematopoietic SH2 domain containing
IDBP-811026
hematopoietic SH2 domain containing
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16134028-16158575
Strand Forward strand
Band p13.11
Transcripts
ENST00000535834
ENST00000593031 ENSP00000467189
ENST00000586872 ENSP00000468495
ENST00000591154 ENSP00000468142
ENST00000616645 ENSP00000482604
ENST00000613986 ENSP00000483354
ENST00000616070 ENSP00000477674
ENST00000613195 ENSP00000483685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0002903 negative regulation of B cell apoptotic process
GO:0009967 positive regulation of signal transduction
GO:0042110 T cell activation
GO:0051902 negative regulation of mitochondrial depolarization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062007
View Gene Order
ENSBTAG00000038154
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631617
RefSeq NM_001291274 NM_032855
HUGO
OMIM
CCDS CCDS74304
HPRD 12219
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca