InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCM8

Summary

InnateDB Protein

IDBP-811503.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM8

Protein Name

minichromosome maintenance complex component 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000478141

InnateDB Gene

IDBG-51957 (MCM8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006974	cellular response to DNA damage stimulus
GO:0007292	female gamete generation
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0048232	male gamete generation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0097362	MCM8-MCM9 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR003593 AAA+ ATPase domain
IPR011704 ATPase, dynein-related, AAA domain
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493
PF07728

PRINTS

PR01657

PIRSF

SMART

SM00350
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt