InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APC

Summary

InnateDB Protein

IDBP-811555.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APC

Protein Name

adenomatous polyposis coli

Synonyms

BTPS2; DP2; DP2.5; DP3; GS; PPP1R46;

Species

Homo sapiens

Ensembl Protein

ENSP00000473355

InnateDB Gene

IDBG-37007 (APC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	194 [view]
Protein-Protein	192 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006974	cellular response to DNA damage stimulus
GO:0007026	negative regulation of microtubule depolymerization
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016477	cell migration
GO:0030178	negative regulation of Wnt signaling pathway
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR016024 Armadillo-type fold

PFAM

PF00514

PRINTS

PIRSF

SMART

SM00185

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

R4GMU6

UniProt Splice Variant

Entrez Gene

324

UniGene

RefSeq

HUGO

HGNC:583

OMIM

611731

CCDS

HPRD

IMGT

EMBL

AC008575 AC136500 AH009132 AH009913

GenPept

AAF34355 AAG25599