Version 5.4
Homo sapiens Protein: CNOT6
Summary
InnateDB Protein IDBP-811783.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT6
Protein Name CCR4-NOT transcription complex, subunit 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000481893
InnateDB Gene IDBG-62304 (CNOT6)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF00560
PF13504
PF13855
PF03372
PF14529
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 57472
UniGene
RefSeq
HUGO HGNC:14099
OMIM 608951
CCDS CCDS4455
HPRD
IMGT
EMBL AB033020 BC152469 CH471165
GenPept AAI52470 BAA86508 EAW53752 EAW53753

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca